PUBLICATIONS

PREPRINTS

Ren, E., Kim S., Mohamad, S., Huguet, S.F.. Shi, Y., Cohen A.R., Piddini, E. & Carazo Salas R.E. Deep learning-enhanced morphological profiling predicts cell fate dynamics in real-time in hPSCs. bioRxiv. 2021. doi: https://doi.org/10.1101/2021.07.31.454574.

Baumgartner, M.E., Langton, P.F., Mastrogiannopoulos, A., Logeay, R. & Piddini, E. PECAn, a pipeline for image processing and statistical analysis of complex mosaic 3D tissues bioRxiv 2021 doi.org/10.1101/2021.07.06.451317.

Baumgartner M.E, Kucinski I., Piddini E. Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in Drosophila. bioRxiv 2021.05.10.443504; doi: https://doi.org/10.1101/2021.05.10.443504

Kim S, Ren E, Marco Casanova P, Piddini E, Carazo Salas RE. Multiplexed live visualization of cell fate dynamics in hPSCs at single-cell resolution. bioRxiv. 2021 Jan 31. doi: https://doi.org/10.1101/2021.01.30.428961.

Publications

Kozyrska K, Pilia G, Vishwakarma M, Wagstaff L., Goschorska M, Cirillo S, Mohamad S, Gallacher K, Carazo Salas R E and Piddini E. p53 directs leader cell behaviour, migration and clearance during epithelial repair.  Science, 2022 Feb 11;375(6581):eabl8876. 10.1126/science.abl8876

Langton, P.F., Baumgartner, M.E., Logeay, R. & Piddini, E. Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status. Plos Genetics, 2021, https://doi.org/10.1371/journal.pgen.1009946 and bioRxiv. 2021. https://doi.org/10.1101/2021.07.02.450835.

Baumgartner ME, Piddini E. Mechanical cell competition in human pluripotent stem cell cultures. Dev Cell. 2021 56(17):2401-2402. doi: 10.1016/j.devcel.2021.08.011. Epub 2021 Sep 13.PMID: 34520762.

Baumgartner ME, Dinan MP, Langton PF, Kucinski I, Piddini E. Proteotoxic stress is a driver of the loser status and cell competition. Nat Cell Biol. 2021 Jan 25. doi: 10.1038/s41556-020-00627-0.

Vishwakarma M, and Piddini E. Outcompeting Cancer. Nat Rev Cancer. 2020 Mar;20(3):187-198. doi: 10.1038/s41568-019-0231-8. Epub 2020 Jan 13.

Piddini E., McNeill H. Editorial overview: Cell dynamics: Dynamic cell decision making. Curr Opin Cell Biol. 2017 Aug 10. pii: S0955-0674(17)30108-4. doi: 10.1016/j.ceb.2017.07.003.

Kucinski I, Dinan M, Kolahgar G, and Piddini E. Chronic activation of JNK, JAK/STAT and oxidative stress signalling causes the loser cell status. Nature Comm. 2017 Jul 26;8(1):136. doi: 10.1038/s41467-017-00145-y.

Balasooriya GI, Goschorska M, Piddini E and Rawlins EL. FGFR2 is required for airway basal cell self-renewal via SOX2 maintenance. Development. 2017 May 1;144(9):1600-1606. doi: 10.1242/dev.135681.

Piddini E. Epithelial Homeostasis: a Piezo of the Puzzle. Dispatch. Curr. Biol. 2017 Mar 20;27(6):R232-R234. doi: 10.1016/j.cub.2017.02.002.

Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, Hampton-O’Neil L, Bradshaw CR, Allen GE, Rawlins EL, Silberzan P, Carazo Salas RE and Piddini E. Mechanical cell competition kills cells via induction of lethal p53 levels. Nature Comm. 2016, 7, 11373.

Suijkerbuijk SJE, Kolahgar G, Kucinski I, Piddini E. Cell competition drives the growth of intestinal adenomas in Drosophila. Curr. Biol. 2016 Feb 22;26(4):428-38. Recommended by the Faculty of 1000.

Kolahgar G, Suijkerbuijk SJE, Poirier E, Mansour S, Simons BD and Piddini^, E. Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT dependent manner. Dev. Cell. 2015 Aug 10;34(3):297-309 Featured Article. Recommended by the Faculty of 1000.

Graml V, Studera X, Lawson JL, Chessel A, Geymonat M, Bortfeld-Miller M, Walter T, Wagstaff L, Piddini E, Carazo-Salas RE. A genomic multi-process survey of the machineries that control and link cell shape, microtubule organisation and cell cycle progression. Dev. Cell. 2014 Oct 27;31(2):227-39. Journal Cover.

Wagstaff L., Kolahgar G, and Piddini E. Competitive cell interactions in cancer: a cellular tug of war. Review. Trends in Cell Biology 2013, 23, 160–167.

Vivarelli S, Wagstaff L and Piddini E. Cell wars: regulation of cell survival and proliferation by cell competition. Review. Essays Biochem. 2012 Aug 10;53(1):69-82.

Vincent JP, Kolahgar G, Gagliardi M, and Piddini E. Steep differences in Wingless signalling trigger Myc-independent competitive cell interactions. Dev. Cell. 2011 21, 366-374. Recommended by the Faculty of 1000.

Hogan C, Dupré-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-López LA, Vincent JP, Itoh Y, Hosoya H, Pichaud F, Fujita Y. Characterisation of the interface between normal and transformed epithelial cells. Nat. Cell. Biol. 2009 Apr;11(4):460-7.

Piddini, E., and Vincent, J.P. Interpretation of the Wingless gradient requires signalling-induced self-inhibition. Cell. 2009 Jan 136, 296-307. Featured Article. Recommended by the Faculty of 1000.

Gagliardi M, Piddini E, and Vincent JP. Endocytosis: a positive or a negative influence on Wnt signalling?.Traffic. 2008 Jan;9(1):1-9. Review.

Piddini E, Marshall F, Dubois L, Hirst E, Vincent JP. Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs. Development. 2005 Dec;132(24):5479-89.

Franch-Marro X, Marchand O, Piddini E, Ricardo S, Alexandre C, Vincent JP. Glypicans shunt the Wingless signal between local signalling and further transport. Development. 2005 Feb;132(4):659-66.

Piddini E, Vincent JP. Modulation of developmental signals by endocytosis: different means and many ends. Curr Opin Cell Biol. 2003 Aug;15(4):474-81. Review.

Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Kocher T, Piddini E, Griffiths G, Way M. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003 Apr 14;161(1):33-9.

Rodriguez J.A., Piddini. E, Hasegawa T, Miyagi T. and Dotti C.G. Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture. J. Neurosci. 2001 Nov 1;21(21):8387-95.

Piddini. E, Schmid J.A., de Martin R. and Dotti C.G. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO J. 2001 Aug 1;20(15):4076-4087.

Feo S, Arcuri D, Piddini E, Passantino R, Giallongo A. ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). FEBS Lett. 2000 May 4;473(1):47-52.

Mangano R, Piddini E, Carramusa L, Duhig T, Feo S, Fried M. Chimeric amplicons containing the c-myc gene in HL60 cells. Oncogene. 1998 Nov 26;17(21):2771-7.

 

 

Baumgartner ME, Dinan MP, Langton PF, Kucinski I, Piddini E. Proteotoxic stress is a driver of the loser status and cell competition. Nat Cell Biol. 2021 Jan 25. doi: 10.1038/s41556-020-00627-0.

Vishwakarma M, and Piddini E. Outcompeting Cancer. Nat Rev Cancer. 2020 Mar;20(3):187-198. doi: 10.1038/s41568-019-0231-8. Epub 2020 Jan 13.

Piddini E., McNeill H. Editorial overview: Cell dynamics: Dynamic cell decision making. Curr Opin Cell Biol. 2017 Aug 10. pii: S0955-0674(17)30108-4. doi: 10.1016/j.ceb.2017.07.003.

Kucinski I, Dinan M, Kolahgar G, and Piddini E. Chronic activation of JNK, JAK/STAT and oxidative stress signalling causes the loser cell status. Nature Comm. 2017 Jul 26;8(1):136. doi: 10.1038/s41467-017-00145-y.

Balasooriya GI, Goschorska M, Piddini E and Rawlins EL. FGFR2 is required for airway basal cell self-renewal via SOX2 maintenance. Development. 2017 May 1;144(9):1600-1606. doi: 10.1242/dev.135681.

Piddini E. Epithelial Homeostasis: a Piezo of the Puzzle. Dispatch. Curr. Biol. 2017 Mar 20;27(6):R232-R234. doi: 10.1016/j.cub.2017.02.002.

Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, Hampton-O’Neil L, Bradshaw CR, Allen GE, Rawlins EL, Silberzan P, Carazo Salas RE and Piddini E. Mechanical cell competition kills cells via induction of lethal p53 levels. Nature Comm. 2016, 7, 11373.

Suijkerbuijk SJE, Kolahgar G, Kucinski I, Piddini E. Cell competition drives the growth of intestinal adenomas in Drosophila. Curr. Biol. 2016 Feb 22;26(4):428-38. Recommended by the Faculty of 1000.

Kolahgar G, Suijkerbuijk SJE, Poirier E, Mansour S, Simons BD and Piddini^, E. Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT dependent manner. Dev. Cell. 2015 Aug 10;34(3):297-309 Featured Article. Recommended by the Faculty of 1000.

Graml V, Studera X, Lawson JL, Chessel A, Geymonat M, Bortfeld-Miller M, Walter T, Wagstaff L, Piddini E, Carazo-Salas RE. A genomic multi-process survey of the machineries that control and link cell shape, microtubule organisation and cell cycle progression. Dev. Cell. 2014 Oct 27;31(2):227-39. Journal Cover.

Wagstaff L., Kolahgar G, and Piddini E. Competitive cell interactions in cancer: a cellular tug of war. Review. Trends in Cell Biology 2013, 23, 160–167.

Vivarelli S, Wagstaff L and Piddini E. Cell wars: regulation of cell survival and proliferation by cell competition. Review. Essays Biochem. 2012 Aug 10;53(1):69-82.

Vincent JP, Kolahgar G, Gagliardi M, and Piddini E. Steep differences in Wingless signalling trigger Myc-independent competitive cell interactions. Dev. Cell. 2011 21, 366-374. Recommended by the Faculty of 1000.

Hogan C, Dupré-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-López LA, Vincent JP, Itoh Y, Hosoya H, Pichaud F, Fujita Y. Characterisation of the interface between normal and transformed epithelial cells. Nat. Cell. Biol. 2009 Apr;11(4):460-7.

Piddini, E., and Vincent, J.P. Interpretation of the Wingless gradient requires signalling-induced self-inhibition. Cell. 2009 Jan 136, 296-307. Featured Article. Recommended by the Faculty of 1000.

Gagliardi M, Piddini E, and Vincent JP. Endocytosis: a positive or a negative influence on Wnt signalling?.Traffic. 2008 Jan;9(1):1-9. Review.

Piddini E, Marshall F, Dubois L, Hirst E, Vincent JP. Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs. Development. 2005 Dec;132(24):5479-89.

Franch-Marro X, Marchand O, Piddini E, Ricardo S, Alexandre C, Vincent JP. Glypicans shunt the Wingless signal between local signalling and further transport. Development. 2005 Feb;132(4):659-66.

Piddini E, Vincent JP. Modulation of developmental signals by endocytosis: different means and many ends. Curr Opin Cell Biol. 2003 Aug;15(4):474-81. Review.

Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Kocher T, Piddini E, Griffiths G, Way M. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003 Apr 14;161(1):33-9.

Rodriguez J.A., Piddini. E, Hasegawa T, Miyagi T. and Dotti C.G. Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture. J. Neurosci. 2001 Nov 1;21(21):8387-95.

Piddini. E, Schmid J.A., de Martin R. and Dotti C.G. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO J. 2001 Aug 1;20(15):4076-4087.

Feo S, Arcuri D, Piddini E, Passantino R, Giallongo A. ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). FEBS Lett. 2000 May 4;473(1):47-52.

Mangano R, Piddini E, Carramusa L, Duhig T, Feo S, Fried M. Chimeric amplicons containing the c-myc gene in HL60 cells. Oncogene. 1998 Nov 26;17(21):2771-7.